Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations

Fig. 3

Genome-wide analysis revealed that nuclear TfR1-binding gene promoters are strongly associated with p53. a Heatmaps of p53 and TfR1 CUT&Tag peaks near the TSSs in HCT-116 cells obtained via anti-p53 and anti-TfR1 antibodies, respectively. IgG served as a control. Raw read densities were used. Each horizontal line indicates an individual gene locus. b CUT&Tag read density plot for p53 and TfR1 at TfR1-bound gene loci. c Venn diagram overlap analysis of p53 and TfR1 peaks. d Pie chart analysis of the proportion of TfR1 peaks overlapping with p53. e TfR1 and p53 peaks classified by human genomic annotations (hg38). f Top consensus motifs identified by de novo motif discovery at the TfR1 and p53 sites on promoters. g Linear correlation between the signals of the p53 and TfR1 peaks. R, the coefficient of determination of the two correlations. h CUT&Tag read density plot for shSCR and shTP53 cells at TfR1-bound gene loci. i Dot plot of the GO term enrichment analysis results for the TfR1 peaks. j CUT&Tag peak distribution for TfR1 at representative gene loci

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