Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma

Fig. 3

CNV characteristics and mutational signature profiles in ESCC. a CNV characteristics across different pathological stages of ESCC. b Pseudo-temporal order for genomic events in ESCC. Probability distributions represent the uncertainty in the timing of specific events within the cohort, with event prevalence displayed as a bar plot on the top. A higher event position value indicates that the event occurred later in the pseudo-temporal order by MutationTimeR. c Identification of mutation signatures and its similar COSMIC signatures in ESCC. Part of signatures was presented in Extended Data Fig. 3B. d, e Comparison of ESCC mutational signatures between nLNM and LNM groups, as well as between stages I–II and stages III–IV. T-test, *, **, ***, **** indicate p-values < 0.05, <0.01, <0.001 and <0.0001, respectively

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