Fig. 1
From: Mitochondrial metabolism and cancer therapeutic innovation
Milestone events in the study of mitochondrial metabolism in cancer. From the Warburg effect (1920s) to recent innovations such as spatial mitochondrial network mapping (2023) and single-cell mtDNA sequencing (2024), this timeline traces key discoveries in mitochondrial cancer research. Major breakthroughs include investigations of mitochondrial structural anomalies, tumor-suppressive metabolic enzymes, apoptosis regulation, and multi-omics integration. These findings have deepened our understanding of the roles of mitochondria in cancer metabolism, heterogeneity, and therapeutic targeting. SCI-LITE single-cell mitochondrial DNA lineage tracing and editing, mtDNA mitochondrial DNA, TCA cycle tricarboxylic acid cycle, BCL B-cell lymphoma 2. This figure was created with BioRender (https://biorender.com/)
