Fig. 7
From: Mitochondrial metabolism and cancer therapeutic innovation
Representative mitochondrial therapeutic targets and their modulators. The figure illustrates four major intervention areas in mitochondrial-targeted therapy: (1) electron transport chain inhibitors, which target complexes I-IV; (2) mitochondrial metabolism modulators, which include regulators of lipid metabolism, glucose metabolism, one-carbon metabolism, and glutamine metabolism; (3) apoptosis pathway modulators, which include Bcl-2/Bcl-xl inhibitors and mitochondrial-derived activators of caspases; and (4) mitochondrial homeostasis modulators, which include Hsp90 inhibitors, ClpP agonists, fission modulators, and Na+/Ca2+ exchanger modulators. BAX BCL-2-associated X protein, BCL-2 B-cell lymphoma 2, ClpP caseinolytic peptidase P, DRP dynamin-related protein 1, OPA1 optic atrophy 1, TCA cycle tricarboxylic acid cycle. This figure was created with BioRender (https://biorender.com/)
