Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential

Fig. 2

Regulatory mechanisms for Treg cell stability. a Treg cell stability can be influenced by epigenetic modifications such as DNA methylation. For instance, the promoter of Foxp3 is usually demethylated to activate Foxp3 expression. b The expression of Foxp3 and other genes specific to Treg cells, such as TGF-β and IL-10, is precisely regulated by crucial transcription factors, including NFAT, STAT5, and Runx. This figure was created with Biorender.com

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