Fig. 3
From: Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential
Treg cell plasticity. Tregs are reprogrammed into Th-like Tregs in response to various cytokines. Th1-like Tregs are induced by IL-12, IL-27, and IFN-γ; Th2-like Tregs are induced by IL-2, IL-4, IL-13, and IL-33; Th17-like Tregs are induced by IL-1β, IL-6, IL-17, IL-21, and IL-23; and Tfr-like Tregs are induced by IL-6 and IL-21.544 This figure was created with Biorender.com
