Fig. 7
From: Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential
Treg cells exhibit a variety of targeting strategies in human diseases. The figure demonstrates the application of Treg cell therapies, such as the infusion of Tregs in diseases. Moreover, inhibitory molecules such as CTLA4 and stimulatory molecules such as GITR can enhance antitumor efficacy, and they have demonstrated potential application prospects in a variety of other diseases. Targeted modulation is achieved through pathways such as CCL22-CCR4, CCL1-CCR8, and CCL28-CCR10, as well as strategies for promoting the proliferation and function of Treg cells via the use of low doses of IL-2 and IL-2 derivatives. Additionally, the effects of the gut microbiome, epigenetic/histone deacetylase inhibitors, fecal microbiota transplantation, CRISPR–Cas9 gene editing, synthetic biology methods, and dietary changes that alter the structure of the gut microbiota on Treg function are also discussed. This figure was created with Biorender.com
