Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Single amino acid substitution in Hendra virus attachment glycoprotein induces cross-neutralizing antibodies against Nipah virus

Fig. 5

Crystal structure of the 14F8 Fab–HeV-GS586N complex. a, b Crystal structure of the 14F8 Fab–HeV-GS586N complex. Residues from CDRH1, CDRL, and FRH of 14F8 that are involved at the interaction interface are displayed as colored sticks. c Detailed interactions between 14F8 Fab and HeV-GS586N. The 14F8 heavy and light chains and belonging residues are shown in cyan and green, respectively, and HeV-GS586N is in gray. The residues in HeV-GS586N are in orange. The red dashed lines represent hydrogen bonds. 14F8-binding regions on NiV-G (d), HeV-G (e), and HeV-GS586N (f); the amino acids forming the local binding grooves are displayed as sticks. Residues belonging to 14F8 CDRL1 are displayed in orange, and the hydrogen bonds are represented by orange dashes

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