Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer

Fig. 2

Heterogeneity of epithelial cell subtypes. a tSNE plot illustrating nine epithelial cell subtypes identified from scRNA-seq data. b Dot plot showing the expression levels of marker genes in each subtype. Dot size and color indicate the percentage and mean expression level of each gene. c Functional annotation of nine subtypes. d Boxplot displaying large-scale copy number variations (CNVs) in six subtypes (goblet, enterocytes, PMC_2, PC, MSC, and cancer) compared to PMC_1, GMC, and enteroendocrine subtypes. Each color indicates one subtype. e Distribution of the nine cell subtypes across N, IM, and T regions in the ST data from each patient. f Unsupervised clustering analysis based on the proportions of epithelial subtypes across normal, IM, and cancer regions. g Pseudotime trajectory analysis of epithelial cells derived from scRNA-seq data from all single-cell samples. h Functional analysis comparing PMC_2 to PMC_1

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