Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Molecular signatures of skeletal muscle insulin resistance: bringing personalised diabetes treatment a step closer

Fig. 1

High-resolution mass spectrometry analysis was performed on skeletal muscle biopsies from euglycaemic individuals and patients with T2D, revealing the muscle proteome and phosphoproteome correlated with whole-body insulin sensitivity rather than diabetic status. Specific insulin resistance signatures were detected during insulin stimulation, with both Akt and mTOR pathways correlating with insulin sensitivity. Sex-specific differences in both proteome and phosphoproteome were also observed. Illustration uses icons by Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

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