Table 2 McDonald 2017 diagnostic criteria for multiple sclerosis
From: Multiple sclerosis: molecular pathogenesis and therapeutic intervention
Category | Diagnostic criteria |
|---|---|
Dissemination in space (DIS) | ≥2 clinical attacks with objective evidence of ≥2 lesions OR MRI lesions in ≥2 characteristic CNS regions: - Periventricular - Cortical/Juxtacortical - Infratentorial - Spinal cord |
Dissemination in time (DIT) | ≥2 clinical attacks separated by ≥1 month OR MRI evidence of the simultaneous presence of gadolinium-enhancing and nonenhancing lesions OR New T2 lesions appearing on follow-up MRI OR Presence of CSF-restricted oligoclonal bands (in patients with clinical and radiological evidence of DIS) |
Diagnosis of RRMS | Evidence of both DIS and DIT demonstrated clinically, via MRI, or with supportive CSF findings (oligoclonal bands) |
Diagnosis of PPMS | ≥1 year of disability progression independent of clinical relapses PLUS 2 of the following: -≥1 T2-hyperintense lesions characteristic of MS in periventricular, cortical/juxtacortical, or infratentorial regions -≥2 T2-hyperintense spinal cord lesions -Presence of CSF-restricted oligoclonal bands |
