Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling

Fig. 4

Transcriptomic response of J-Lat 8.4 and 10.6 cells to holo-RBP4. a Volcano plot depicting the differentially expressed genes in untreated J-Lat 10.6 versus 8.4 cells as assessed by RNAseq and deseq2. Log2 fold change of N = 3 (biological replicates), to control he false discovery rate significances given as threshold-adjusted p values. Volcano plot of the differential expressed genes in b J-Lat 8.4 or c 10.6 cells treated with holo-RBP4 as assed by RNAseq and deseq2 analysis. Log2 fold change of N = 3 (biological replicates), to control the false discovery rate significances given as threshold-adjusted p values. d Heatmap depicting the top 40 differentially regulated genes in J-Lat 10.6 cells, individual biological replicates treated as indicated. Genes and replicates are grouped by hierarchical clustering and the expression values z-score normalized. e Gene Ontology Term enrichment analysis driven by EnrichR of the significantly upregulated genes in (c). f Chip-X prediction of the major transcription factors driving expression of the significant genes in (c)

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