Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

Fig. 1

Schematics of LRP1 shuttling across brain endothelial cells (a) following either the PACSIN2 or Rab5 pathway and its relationship with multivalent cargo. LPR1 expression in brain endothelial cells (b) as a function of cargo valency. The latter represents the average number of ligands per cargo that interact with LRP1, with n = 1 representing a single peptide. The data are replotted from refs. 31,32

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