Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia

Fig. 4

Genetic validation of PC and SM using plasma and brain metabolite PRS in independent datasets. a Plasma phospholipids PRS between TR and NTR. Data are shown as mean ± SD (n = 2281). b Brain phospholipids PRS between TR and NTR. Data are shown as mean ± SD (n = 449). Brain phospholipids PRS for DLPFC-Parietal-Temporal and DLPFC-Temporal cortices are shown separately. DLPFC dorsolateral prefrontal cortex, PC phosphatidylcholine, PRS polygenic risk score, SM sphingomyelin. *P < 0.05

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