Fig. 2
Bulk RNA-seq analysis of HlaH35A treated Fl-BMDCs compared with control Fl-BMDCs subjected to antigen treatment. a Heatmap of representative gene expression in Fl-BMDCs after 7.5 h of treatment with HPF or PA0833. The relative expression abundance (rowwise Z score of the log2(TPM + 1), where TPMs denote transcripts per million; color scale) of genes (rows) across conditions (columns) is shown. b DEGs (|log2-fold change| > 1 and P value < 0.05) in Fl-BMDCs treated with HPF vs. PA0833. Upregulated genes: 257; downregulated genes: 307. c KEGG analysis of upregulated genes in Fl-BMDCs after 7.5 h of treatment with HPF vs. PA0833. Red indicates T-cell response-related signals, and orange indicates PRR-related signals. d GO enrichment analysis of upregulated genes in Fl-BMDCs after 7.5 h of treatment with HPF or PA0833. Red indicates T-cell response-related signals, blue indicates dendritic cell development-related signals, and orange indicates PRR-related signals. e GSEA showing enrichment of the REACTOME_THE_NLRP3_INFLAMMASOME pathway in Fl-BMDCs treated with HPF vs. PA0833. DEG differentially expressed gene
