Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Single-cell RNA-seq reveals cell type-specific molecular and genetic associations with primary open-angle glaucoma

Fig. 7

SMR analysis reveals that cell type-specific genetic regulation of gene expression is associated with POAG risk. a Manhattan plot of genome-wide summary data-based Mendelian randomization (SMR) results for POAG in NK cells. Each point represents a gene–SNP pair; the horizontal red dashed line indicates the Bonferroni-corrected significance threshold (P_SMR = 2.85 × 10−6). b Supplementary Table 8 summarizing the most significant SMR associations (P_SMR < 1 × 10−5) across immune cell types, including cell type, genomic locus, SNP, target gene, and P_SMR value. c Regional association (locus) plot for rs115322609 in NK cells, showing SMR P values for genes in the region (NXPH3, CACNA1G, SGCA). The red dashed line marks the significance threshold. d Effect size plot for rs115322609 in NK cells, comparing eQTL effect sizes (x-axis) and GWAS effect sizes (y-axis) for NXPH3, CACNA1G, and SGCA. The error bars indicate confidence intervals

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