Table 3 Objective 3, meta-regression analysis of the effect of BMC strategies on (A) locomotor recovery and (B) in vivo axonal regeneration; combinations tested in vivo only.
A Improvement in locomotor outcomes | ||||
|---|---|---|---|---|
Biomaterial-based combination | Effect size (%) | P > | t | | 95% Conf. Interval | Frequency % (n) |
PLGA + combinations | 46.3 | 0.002 | [26.4, 66.3] | 12.8 (6) |
Chitosan + combinations | 19.8 | 0.476 | [0.8, 38.8] | 17 (8) |
Collagen + combinations | 13 | 0.055 | [−0.3, 26.4] | 27.7 (13) |
Fibrin + combinations | 11.3 | 0.845 | [−67, 29.3] | 19.1 (9) |
Other biom. + combinations | 40.1 | 0.004 | [22.3, 57.8] | 23.4 (11) |
comparisons=47, p = 0.0006, Tau2 = 318.4, I2 = 95.9%, adj R2 = 91.72% | ||||
B Improvement in axonal regeneration | ||||
|---|---|---|---|---|
Biomaterial-based combination | Effect size (SD) | P > | t | | 95% Conf. interval | Frequency % (n) |
Chitosan + combinations | 2.1 | 0.263 | [−0.5, 4.8] | 10.9 (5) |
PLGA + combinations | 1.7 | 0.348 | [−0.5, 3.9] | 19.6 (9) |
Matrigel + combinations | 1.5 | 0.53 | [−1, 4] | 10.9 (5) |
Fibrin + combinations | 0.7 | 0.326 | [−0.7, 2] | 21.7 (10) |
Collagen + combinations | 0.5 | 0.869 | [−1.6, 2.6] | 19.6 (9) |
Other biom. + combinations | 2.8 | 0.069 | [0.5, 5.1] | 17.4 (8) |
comparisons=46, p = 0.398, Tau2 = 2.56, I2 = 88.5%, adj R2 = 0% | ||||
