Fig. 2: Skin blood flow during local cooling (LC) is shown as the mean ± SD in cervical (SCIC; n = 9; ●) and thoracolumbar spinal cord injuries (SCITL; n = 9; □).
From: Observations of cold-induced vasodilation in persons with spinal cord injuries

The lateral axis shows the time, with baseline, 33 °C to 15 °C, 15 °C stage, 15 °C to 8 °C, and 8 °C stage. A: mV value on the chest, B: mV value on the thigh, A and B: temperature change between the Peltier device and skin during LC is shown as the mean ± SD in SCIC; n = 9; ○ SCITL; n = 9; ■. C: % change from the baseline value (%Δ) on the chest, D: %Δ on the thigh. The averaged values for the last 5 min of 33 °C was set as the baseline (0 min). Symbols represent statistical significance: †, vs baseline; §, vs 1 min before the onset of each stage (15 and 8 °C LC); SCIC #, vs baseline; ¶, vs 1 min before the onset of each stage (15 and 8 °C LC); SCITL at the level of p value < 0.05. The results of two-way ANOVA repeated measurements of SkBF are shown in the upper left of the figure. [mV] on the chest and thigh were as follows: effects within participants (Time), F (40, 640) = 6.039 and 3.576, p = 0.02 and 0.04; between participants (Group), F (1, 16) = 0.79 and 0.02, p = 0.38 and 0.88; interaction effects of Time × Group, F (40, 640) = 1.20 and 0.84, p = 0.29 and 0.44, respectively. The results of two-way ANOVA repeated measurements of SkBF [%Δ] on the chest and thigh were as follows: effects within participants (Time), F (40, 640) = 15.29 and 9.08, p < 0.001 and 0.004 between participants (Group), F (1, 16) = 2.64 and 2.57, p = 0.12 and 0.13; and interaction effects of Time × Group, F (40, 640) = 0.63 and 0.58, p = 0.52 and 0.50, respectively.