Abstract
Introduction
Calcification of the ligamentum flavum can cause acute neck pain and compression of the spinal cord, which can induce myelopathy. However, there are very few reports of acute exacerbation of myelopathy due to a pseudogout attack of the cervical ligamentum flavum, and there are no reports of that after a cervical spinal cord injury. Here, we report the case of a patient with acute neck pain and tetraplegia caused by pseudogout attack of the cervical ligamentum flavum after cervical central spinal cord injury.
Case presentation
A 78-year-old man experienced mild tetraplegia after falling. He was diagnosed with cervical spinal cord injury without radiographic abnormality. Four days after the injury, he developed fever and his paralysis worsened. Magnetic resonance imaging revealed increasing of spinal stenosis at the C4–5 level. Computed tomography revealed calcification of the ligamentum flavum at the same level. C3 laminectomy and C4-5 laminoplasty were performed. A collection of turbid yellow fluid was found in the ligamentum flavum. A histopathological examination revealed evidence of calcium pyrophosphate dihydrate crystals in the fluid.
Discussion
With increase in the aging population in Japan, the patients with acute exacerbation of myelopathy due to pseudogout in the cervical spine following spinal cord injury without radiographic abnormality may increase in the future. Computed tomography is useful for the diagnosis of such cases.
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References
Richette P, Bardin T, Doherty M. An update on the epidemiology of calcium pyrophosphate dehydrate crystal deposition disease. Rheumatology. 2009;48:711–5.
Miyakoshi N, Suda K, Kudo D, Sakai H, Nakagawa Y, Mikami Y, et al. A nationwide survey on the incidence and characteristics of traumatic spinal cord injury in Japan in 2018. Spinal Cord. 2020. https://doi.org/10.1038/s41393-020-00533-0.
Kobayashi T, Miyakoshi N, Abe T, Kikuchi K, Noguchi H, Konno N, et al. Acute neck pain caused by pseudogout attack of calcified cervical yellow ligament: a case report. J Med Case Rep. 2016;10:133.
Baba H, Maezawa Y, Kawahara N, Tomita K, Fukusawa N, Imura S. Calcium crystal deposition in the ligamentum flavum of the cervical spine. Spine. 1993;18:2174–81.
Rosenthal AK, Ryan LM. Calcium pyrophosphate crystal deposition disease, pseudogout, and articular chondrocalcinosis. In: William J. Koopman, Larry W. Moreland editors. Arthritis and allied conditions: a textbook of Rheumatology. Williams & Wilkins, 2001; pp 2348–71.
Yelamarthy PKK, Chhabra HS, Vaccaro A, Vishwakarma G, Kluger P, Nanda A, et al. Management and prognosis of acute traumatic cervical central cord syndrome: systematic review and Spinal Cord Society-Spine Trauma Study Group position statement. Eur Spine J. 2019;28:2390–407.
Statistics Bureau of Japan. Current Population Estimate as of October 1, 2019. https://www.stat.go.jp/english/data/jinsui/2019np/index.html#a15k01-a. Accessed 24 Aug 2020.
Kudo D, Miyakoshi N, Hongo M, Kasukawa Y, Ishikawa Y, Ishikawa N, et al. An epidemiological study of traumatic spinal cord injuries in the fastest aging area in Japan. Spinal Cord. 2019;57:509–15.
Felson DT, Anderson JJ, Naimark A, Kannel W, Meenan RF. The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham study. J Rheumatol.1989;16:1241–5.
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The authors thank Takeshi Ino for his help in date collection.
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Kimura, R., Miyakoshi, N., Kobayashi, T. et al. Acute exacerbation of cervical myelopathy caused by pseudogout of the cervical ligamentum flavum after cervical spinal cord injury: a case report. Spinal Cord Ser Cases 6, 98 (2020). https://doi.org/10.1038/s41394-020-00348-4
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DOI: https://doi.org/10.1038/s41394-020-00348-4