Fig. 1
From: Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota
Circulating succinate levels are increased in obesity and type 2 diabetes. a Circulating plasma levels in lean, obese and type 2 diabetes (T2DM) individuals. Data are expressed as median and interquartile range. Differences were analyzed by the Kruskal–Wallis test with post hoc Dunn’s multiple comparison test. *p < 0.0001 vs. lean. b Positive correlation between succinate levels and BMI, insulin, glucose, HOMA-IR, and triglycerides using the entire cohort. c Negative correlation between succinate levels and levels of SAT ATGL, SAT ABHD5, SAT HSL, and SAT ZAG. d Positive correlation between succinate levels and SAT HIF1A and SAT CD163. SAT; subcutaneous adipose tissue. Statistical analyses for b–d: Spearman’s correlation analysis. See also Table Supplementary S1 for all clinical characteristics of this cohort
