Fig. 3
From: Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota
Weight loss induced by dietary intervention modifies specific gut microbiota and impacts circulating succinate levels. a Circulating serum succinate levels in basal state and after a 12-week dietary intervention (12-wDI) from cohort IV. b Percentage of incidence within Bacteroidetes and Firmicutes families in obese individuals in basal state and after 12-wDI. c Positive correlation between the change in succinate serum levels (12-wDI[succinate]-basal[succinate]) and the change in Prevotellaceae (12-wDI [% abundance Prevotellaceae]-basal[% abundance Prevotellaceae]). d Differences between basal state and 12-wDI in the fam(P + V/O + C) ratio. e Positive correlation between the change in succinate serum levels (12-wDI[succinate]-basal[succinate]) and the change in the (12-wDI fam(P + V/O + C)–basal fam(P + V/O + C)) ratio. See also Supplementary Table S3 for all clinical characteristics of cohort IV. Data information: for a and b values are expressed as mean ± SD. For d, data are represented in box and whisker plot format (whiskers: min to max). Statistical analyses: Wilcoxon signed-rank test. *p < 0.05 vs. basal. For c and d, Spearman’s correlation analysis with Bonferroni adjustment was used
