Fig. 1: Inhibiting QS results in reduced phage sensitivity and prolonged phage persistence at low phage densities. | The ISME Journal

Fig. 1: Inhibiting QS results in reduced phage sensitivity and prolonged phage persistence at low phage densities.

From: The effect of Quorum sensing inhibitors on the evolution of CRISPR-based phage immunity in Pseudomonas aeruginosa

Fig. 1

Observed resistance mechanism evolution in P. aeruginosa PA14 WT or surface mutant (sm) supplemented with DMSO (dark grey bars/points) or 100 µM QS inhibitor Baicalein (light grey bars/points) and at 3 days post infection with (A) 104 pfu (B) 107 pfu (C) 109 pfu of phage DMS3vir. Bars represent mean proportions of each of the different bacterial phenotypes (i.e., the proportion of bacteria in the population that evolved CRISPR immunity, acquired surface mutations or that remained sensitive), error bars indicate 95% confidence interval, points represent individual replicates, N = 6.

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