Fig. 2: Phage are less able to infect hosts when QS is inhibited. | The ISME Journal

Fig. 2: Phage are less able to infect hosts when QS is inhibited.

From: The effect of Quorum sensing inhibitors on the evolution of CRISPR-based phage immunity in Pseudomonas aeruginosa

Fig. 2

A Phage adsorption over time (3–50 min) when WT P. aeruginosa is infected with phage when supplemented with DMSO (control) (dark grey line) or 100 µM QS inhibitor Baicalein (light grey line). Samples were taken at 3, 6, 9, 12, 15, 20, 25, 30, 40 and 50 min post infection. Lines represent mean % of free phage particles detected, N = 3 (B) Titre of phage remaining at 24hpi of a CRISPR resistant host possessing two unique spacers targeting the infecting phage (BIM2) when initially infected with 109 phage. Bars represent mean titre of phage present at 24hpi, error bars indicate 95% confidence interval, points represent individual replicates, N = 6, Y axis is log10 scale.

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