Fig. 3: The SNP profile of the target species in each group.

A, D, G (top panel) The number of SNPs annotated in the three species among the three groups, and the mutational frequency of each SNPs annotated in the three intestinal species. A, D, G (bottom panel) The correlation analysis revealed a high consistency between the relative abundance and the number of SNPs of the mutational species. B, E, H Genomic locations and contexts of SNPs in the species of Bacteroides vulgatus (B, n = 90), Faecalibacterium prausnitzii (E, n = 119) and Eubacterium rectale (H, n = 66), which exhibited the significant difference in mutational frequency between the healthy and GD groups. C, F, I The functions of the mutated genes (red) carried the SNP markers were annotated at the bottom panel.