Fig. 2: Differentially abundant serum metabolites and their clusters. | The ISME Journal

Fig. 2: Differentially abundant serum metabolites and their clusters.

From: Altered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Fig. 2

By analyzing the serum metabolomic profiles of 259 IBS and 66 HC from the discovery cohort, we identified 726 differentially abundant serum metabolites (including 364 identified in the positive mode and 362 identified in the negative mode), among which 101 out of the 726 metabolites were structurally identified. a The barplot shows the PLS-DA VIP results in the projection of the 101 structurally identified differentially abundant serum metabolites. b Diet-associated differentially abundant serum metabolites that enriched in IBS patients and in healthy controls. The Y-axis represents each metabolite, and the X-axis shows the log-transformed PPM units of the abundance of each metabolite. c The largest cluster enriched in IBS contained 70 metabolites, and all of them significantly elevated among IBS patients. d One interesting cluster enriched in healthy controls contained 46 metabolites and included a variety of amines, all of which significantly elevated in healthy controls. Abundances are in log-transformed PPM units.

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