Fig. 5: Aberrant metabolomic and metagenomic patterns in IBS patients with and without depression. | The ISME Journal

Fig. 5: Aberrant metabolomic and metagenomic patterns in IBS patients with and without depression.

From: Altered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Fig. 5

a, b PLS-DA score plots based on the serum metabolomic profiles of 259 IBS patients (including 181 rIBS, 62 mIBS, and 16 sIBS) and 66 healthy controls form the discovery cohort in both positive and negative ionization modes. c, d PLS-DA score plots based on fecal metabolomic profiles of 264 IBS patients (including 185 rIBS, 63 mIBS, and 16 sIBS) and 66 healthy controls form the discovery cohort in both positive and negative ion modes. e Differentially abundant gut microbiota species among rIBS, mIBS, sIBS, and HC, by using LEfSe to analyze the gut metagenomic profiles of individuals from the discovery cohort. f The relative abundance of L-tryptophan biosynthesis pathway in rIBS, mIBS, sIBS, and HC. Here the abundance of TRP production is inferred by analyzing the fecal metagenomic profiles of 264 IBS and 66 HC from the discovery cohort, not yet measured in situ. g The signal intensity of tryptophan in serum and feces in rIBS, mIBS, sIBS, and HC, by analyzing the serum and fecal targeted metabolic profiles of individuals from the discovery cohort.

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