Fig. 4
From: Drug–drug–gene interactions and adverse drug reactions
Drug transporters as classified into three categories according to the similarity of the transport directions in different tissue types. Numbers from 
to 
= order of oral drug movement through different tissue types. Nonoral drug formulations bypass the effect of intestinal transporters. 
/
= increased/decreased substrate drug plasma level is predicted as a result of impairment of this transporter due to LOF variants or inhibitors. The reverse is predicted with GOF variants or inducers. The presence of the two factors (i.e. LOF variant + an inhibitor or GOF variant + an inducer) is predicted to double the clinical impact with neutralizing or shifting the clinical effect when the preparator drug and genetic effect are opposed (phenoconversion interactions). 
= Apical membrane. 
= Basolateral membrane
