Fig. 5 | The Pharmacogenomics Journal

Fig. 5

From: Meta-analytic method reveal a significant association of theBDNF Val66Met variant with smoking persistence based on a large samples

Fig. 5

The BDNF gene expression in different 53 human tissues and rs6265-eQTL analysis. a For BDNF gene expression. The source of expression data were attained from GTEx analysis release V7 (dbGaP Accession phs000424.v7.p2). Expression values are shown in transcripts per million (TPM). Box plots are presented as median, 25th and 75th percentiles; points are shown as outliers if the value above or below 1.5 times the interquartile range. b The Human BDNF gene structure. The 10 introns are presented as black lines and the 11 exons as green boxes. Only the 3’ exon 9 is coding and generates the polypeptide of BDNF. The blue box represents the region of exon 9 coding for the pro-BDNF protein. The functional rs6265 polymorphism is located at the position of 196 in the genomic region encoding the protein of pro-BDNF [31, 58]. c rs6265-eQTL analysis. The cis-acting SNP-eQTL analyses in different human tissues was based on a web-based tool of Haploreg v4.1 (https://pubs.broadinstitute.org/mammals/haploreg/haploreg.php)

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