Table 2 Seropositive autoantibodies associated with patient membership in each cluster.
Autoantibody | ORadj (95% CI) | p-value | Adj p-value |
---|---|---|---|
Cluster 1 (n = 33) – no ACPA reactivity | |||
IL6R | 36.33 (13.13–100.55) | 4.59E–12 | <1E–06 |
IL17RA | 23.39 (9.53–57.39) | 5.80E–12 | <1E–06 |
CD86 | 19.21 (8.13–45.37) | 1.58E–11 | <1E–06 |
CSF2RA | 20.08 (8.38–48.10) | 1.71E–11 | <1E–06 |
CD80 | 18.66 (7.87–44.21) | 2.95E–11 | <1E–06 |
CCL2 | 17.74 (7.52–41.86) | 5.10E–11 | <1E–06 |
TNFSF13 | 16.49 (7.04–38.59) | 1.06E–10 | <1E–06 |
CTSLa | 3.44 (1.58–7.50) | 1.90E–03 | 0.023 |
TLR2a | 3.56 (1.51–8.38) | 3.72E–03 | 0.037 |
IL15a | 3.18 (1.43–7.06) | 4.44E–03 | 0.040 |
Cluster 2 (n = 24) – C4B reactivity | |||
C4Ba | 6.11 (2.35–15.92) | 2.08E–04 | 0.019 |
Cluster 3 (n = 47) – moderate ACPA reactivity, cross-reactivity with Clusters 1 and 4 | |||
CSF2RA | 9.50 (4.44–20.34) | 6.66E–09 | 1E–06 |
CD80 | 9.27 (4.34–19.79) | 8.86E–09 | 1E–06 |
IL17RA | 8.76 (4.17–18.41) | 1.03E–08 | 1E–06 |
CCL2 | 8.96 (4.20–19.11) | 1.41E–08 | 1E–06 |
TNFSF13 | 9.00 (4.14–19.56) | 2.86E–08 | 1E–06 |
CD86 | 8.60 (4.00–18.50) | 3.65E–08 | 1E–06 |
IL6R | 6.99 (3.43–14.25) | 8.87E–0 | 2E–06 |
VIM_c | 3.78 (1.89–7.59) | 1.78E–04 | 0.004 |
SPP1_c | 3.23 (1.64–6.36) | 6.91E–04 | 0.014 |
EIF4H_c | 3.25 (1.55–6.82) | 1.82E–03 | 0.033 |
CLU_c | 2.78 (1.45–5.36) | 2.20E–03 | 0.036 |
Cluster 4 (n = 70) – high ACPA reactivity | |||
SPP1_c | 20.48 (9.30–45.10) | 6.37E–14 | <1E–06 |
RBMS1_ca | 13.92 (6.97–27.80) | 8.89E–14 | <1E–06 |
VIM_c | 30.17 (12.25–74.27) | 1.25E–13 | <1E–06 |
DNAJB1_ca | 12.83 (6.47–25.42) | 2.60E–13 | <1E–06 |
HNRNPA1_ca | 10.54 (5.55–20.02) | 6.37E–13 | <1E–06 |
FN1_ca | 10.23 (5.43–19.30) | 6.58E–13 | <1E–06 |
TRA2B_ca | 10.43 (5.36–20.29) | 5.04E–12 | <1E–06 |
CLU_c | 9.29 (4.85–17.78) | 1.69E–11 | <1E–06 |
NONO_ca | 17.17 (7.28–40.57) | 8.55E–11 | <1E–06 |
SFPQ_ca | 6.92 (3.76–12.75) | 5.35E–10 | <1E–06 |
CPSF6_ca | 6.92 (3.76–12.75) | 1.74E–09 | <1E–06 |
TNC_ca | 5.99 (3.23–11.11) | 1.36E–08 | <1E–06 |
AEBP1_ca | 5.12 (2.76–9.52) | 2.36E–07 | 3E–06 |
EIF4H_c | 130.97 (17.44–983.47) | 2.15E–06 | 2.8E–05 |
ASMTL_ca | 7.45 (10.59–581.40) | 1.96E–05 | 2.37E–04 |
PDIA6_ca | 4.74 (2.29–9.80) | 2.79E–05 | 3.16E–04 |
FGB_ca | 3.49 (1.92–6.34) | 4.34E–05 | 4.62E–04 |
DDX5_ca | 3.79 (1.97–7.26) | 6.14E–05 | 6.17E–04 |
ACTB_ca | 3.33 (1.63–6.82) | 9.86E–04 | 0.001 |
SRSF7_ca | 2.94 (1.52–5.70) | 1.35E–03 | 0.012 |