Table 2 Seropositive autoantibodies associated with patient membership in each cluster.

From: Proteomic analysis to define predictors of treatment response to adalimumab or methotrexate in rheumatoid arthritis patients

Autoantibody

ORadj (95% CI)

p-value

Adj p-value

Cluster 1 (n = 33) – no ACPA reactivity

IL6R

36.33 (13.13–100.55)

4.59E–12

<1E–06

IL17RA

23.39 (9.53–57.39)

5.80E–12

<1E–06

CD86

19.21 (8.13–45.37)

1.58E–11

<1E–06

CSF2RA

20.08 (8.38–48.10)

1.71E–11

<1E–06

CD80

18.66 (7.87–44.21)

2.95E–11

<1E–06

CCL2

17.74 (7.52–41.86)

5.10E–11

<1E–06

TNFSF13

16.49 (7.04–38.59)

1.06E–10

<1E–06

CTSLa

3.44 (1.58–7.50)

1.90E–03

0.023

TLR2a

3.56 (1.51–8.38)

3.72E–03

0.037

IL15a

3.18 (1.43–7.06)

4.44E–03

0.040

Cluster 2 (n = 24) – C4B reactivity

C4Ba

6.11 (2.35–15.92)

2.08E–04

0.019

Cluster 3 (n = 47) – moderate ACPA reactivity, cross-reactivity with Clusters 1 and 4

CSF2RA

9.50 (4.44–20.34)

6.66E–09

1E–06

CD80

9.27 (4.34–19.79)

8.86E–09

1E–06

IL17RA

8.76 (4.17–18.41)

1.03E–08

1E–06

CCL2

8.96 (4.20–19.11)

1.41E–08

1E–06

TNFSF13

9.00 (4.14–19.56)

2.86E–08

1E–06

CD86

8.60 (4.00–18.50)

3.65E–08

1E–06

IL6R

6.99 (3.43–14.25)

8.87E–0

2E–06

VIM_c

3.78 (1.89–7.59)

1.78E–04

0.004

SPP1_c

3.23 (1.64–6.36)

6.91E–04

0.014

EIF4H_c

3.25 (1.55–6.82)

1.82E–03

0.033

CLU_c

2.78 (1.45–5.36)

2.20E–03

0.036

Cluster 4 (n = 70) – high ACPA reactivity

SPP1_c

20.48 (9.30–45.10)

6.37E–14

<1E–06

RBMS1_ca

13.92 (6.97–27.80)

8.89E–14

<1E–06

VIM_c

30.17 (12.25–74.27)

1.25E–13

<1E–06

DNAJB1_ca

12.83 (6.47–25.42)

2.60E–13

<1E–06

HNRNPA1_ca

10.54 (5.55–20.02)

6.37E–13

<1E–06

FN1_ca

10.23 (5.43–19.30)

6.58E–13

<1E–06

TRA2B_ca

10.43 (5.36–20.29)

5.04E–12

<1E–06

CLU_c

9.29 (4.85–17.78)

1.69E–11

<1E–06

NONO_ca

17.17 (7.28–40.57)

8.55E–11

<1E–06

SFPQ_ca

6.92 (3.76–12.75)

5.35E–10

<1E–06

CPSF6_ca

6.92 (3.76–12.75)

1.74E–09

<1E–06

TNC_ca

5.99 (3.23–11.11)

1.36E–08

<1E–06

AEBP1_ca

5.12 (2.76–9.52)

2.36E–07

3E–06

EIF4H_c

130.97 (17.44–983.47)

2.15E–06

2.8E–05

ASMTL_ca

7.45 (10.59–581.40)

1.96E–05

2.37E–04

PDIA6_ca

4.74 (2.29–9.80)

2.79E–05

3.16E–04

FGB_ca

3.49 (1.92–6.34)

4.34E–05

4.62E–04

DDX5_ca

3.79 (1.97–7.26)

6.14E–05

6.17E–04

ACTB_ca

3.33 (1.63–6.82)

9.86E–04

0.001

SRSF7_ca

2.94 (1.52–5.70)

1.35E–03

0.012

  1. aUnique to cluster, "_c" suffix denotes autoantibody in citrullinated form.