Fig. 2: The 33 gene sets that were enriched according to DEPICT were clustered into ten biological themes. | The Pharmacogenomics Journal

Fig. 2: The 33 gene sets that were enriched according to DEPICT were clustered into ten biological themes.

From: Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy

Fig. 2

The reconstituted gene sets were named after the predefined gene sets used in the development of DEPICT, and source databases are reported in brackets. The nominal enrichment p for each reconstituted gene set as reported by DEPICT is reported in brackets, with emphasis added for gene sets with p < 1 × 10−4. Clustering into biological themes was performed using affinity propagation clustering after calculating pairwise Pearson correlation between all enriched gene sets, as depicted in the bubble chart. CEBPB: CCAAT/enhancer binding protein beta, CTNNB1: catenin beta 1, DAG: diacylglycerol, EGFR: epidermal growth factor receptor, ENSG: Ensembl gene, ERBB2: erb-b2 receptor tyrosine kinase 2, GO: gene ontology, IP3: inositol triphosphate, KEGG: Kyoto Encyclopedia of Genes and Genomes, MAP: mitogen-activated protein kinase, MAP2K1: MAP kinase kinase 1, MP: mammalian phenotype ontology, NAT9: N-acetyltransferase 9, NGF: nerve growth factor, NOD1: nucleotide binding oligomerization domain containing 1, PLCG1: phospholipase C, gamma 1, RAC2: ras-related C3 botulinum toxin substrate 2, RAC3: ras-related C3 botulinum toxin substrate 3, RAF1: Raf-1 proto-oncogene, serine/threonine kinase, TCR: T cell receptor; TGOLN2: trans-golgi network protein 2, TRKA: tropomyosin receptor kinase A.

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