Table 2 Pooled genotypic effects of SLCO1B1 gene rs4149056 polymorphisms in Caucasian with specific type of statin.

From: A systematic review and meta-analysis of genotype-based and individualized data analysis of SLCO1B1 gene and statin-induced myopathy

Study	Author	Year	Myopathy					Control					CC vs TT		TC vs TT
			No. of subjects in case	Genotype				No. of subjects in control	Genotype				OR1	95% CI	OR2	95% CI
			No. of subjects in case	TT		TC	CC	No. of subjects in control	TT		TC	CC	OR1	95% CI	OR2	95% CI
Caucasian with statin users
1	Willrich et al. [38]	2018	89	67		21	1	89	57		30	2	0.43	0.04, 4.81	0.60	0.31, 1.15
2	Bakar et al. [39]	2017	125	78		45	2	476	353		112	11	0.82	0.18, 3.79	1.82	1.19, 2.78
3	Mirošević Skvrce et al. [40]	2015	60	34		22	4	90	69		21	0	18.13	0.95, 346.44	2.13	1.03, 4.39
4	Ferrari et al. [41]	2014	33	8		13	12	33	18		13	2	13.50	2.43,74.87	2.25	0.72, 6.99
5	Carr et al. [26]	2013	76	40		30	6	372	260		101	11	3.55	1.24, 10.12	1.93	1.14, 3.27
6	Brunham et al. [42]	2012	25	15		8	2	83	57		20	6	1.27	0.23, 6.92	1.52	0.56, 4.12
7	Donnelly et al. [17]	2011	816	565		227	24	1275	905		348	22	1.75	0.97, 3.15	1.04	0.86, 1.27
8	Linde et al. [44]	2010	27	14		12	1	19	15		4	0	3.21	0.12, 85.20	3.21	0.84, 12.35
9	Voora et al. [45]	2009	97	62		31	4	351	263		84	4	4.24	1.03, 17.43	1.57	0.95, 2.57
10	Link et al. [18]	2008	85	29		35	21	90	70		17	3	16.9	4.68, 61.06	4.97	2.41, 10.24
	Pooled												2.92	(1.59, 5.34)	1.61	(1.20, 2.16)
Caucasian with atorvastatin users
1	Mirošević Skvrce et al. [40]	2015	60	34	22		4	90	69	21		0	18.13	0.95, 346.44	2.13	1.03, 4.39
2	Carr et al. [26]	2013	11	7	4		0	110	86	22		2	2.31	0.10, 52.59	2.23	0.60, 8.32
3	Brunham et al. [42]	2012	10	7	2		1	34	24	7		3	1.14	0.10, 12.78	0.98	0.16, 5.83
	Pooled												3.95	(1.23, 12.63)	1.98	(1.11, 3.52)
Caucasian with simvastatin users
1	Bakar et al. [39]	2017	125	78	45		2	476	353	112		11	0.82	0.18, 3.79	1.82	1.19, 2.78
2	Carr et al. [26]	2013	59	29	25		5	222	147	71		4	6.34	1.60, 25.03	1.78	0.97, 3.27
3	Brunham et al. [42]	2012	12	5	6		1	39	27	10		2	2.70	0.20, 35.75	3.24	0.81, 13.02
4	Donnelly et al. [17]	2011	816	565	227		24	1275	905	348		22	1.75	0.97, 3.15	1.04	0.86, 1.27
5	Link et al. [18]	2008	85	29	35		21	90	70	17		3	16.90	4.68, 61.06	4.97	2.41, 10.24
	Pooled												2.81	(1.17, 6.77)	1.78	(1.15, 2.77)

CI confidence interval, OR odds ratio.

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Table 2 Pooled genotypic effects of SLCO1B1 gene rs4149056 polymorphisms in Caucasian with specific type of statin.

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