Table 1 G6PD missense variants detected within the HAAD and KGA population datasets and their relative stability effect (∆∆G) for G6PD protein.

From: G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19

Variant ID

Nucleotide

Amino Acid

∆∆G (kcal/mol)

Class

rs34193178 G

c.1048 G > C

D350H

0.374

N/A

rs76723693 G

c.968 T > C

L323P

−0.872

III

rs782754619 C

c.634 A > G

M212V

−1.147

N/A

rs181277621 T

c.311 G > A

R104H

−1.401

N/A

chrX:g.153762577 A > G

c.620 T > C

M207T

−1.145

N/A

chrX:g.153775028 C > T

c.58 G > A

N/A

N/A

N/A

rs137852313 T

c.466 G > A

E156K

0.539

III

rs1050829 C

c.376 A > G

N126D

0.887

IV

rs1050828 T

c.202 G > A

V68M

−1.347

III

  1. Class refers to WHO classification.
  2. Nucleotide positions based on cDNA NM_001042351.2 cDNA (chrX:g.153775028 C > T G58A is indicated by NM_000402.4). Amino acid positions based on NP_001035810.1.
  3. N/A not available.
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