Table 3 Summary statistics of meta-analyses.
From: Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis
Authors | Allele/Haplotype | CIA + | CIA− | Control + | Control− | Sensitivity | Specificity | NPVa | PPVa | NNG | OR [95% CI] | | Z | | I2 | p value | pb,a |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dettling 2001, Turbay 1997 | HLA-DRB1*04:02 | 14 | 40 | 8 | 123 | 26% | 94% | 99.3% | 3.8% | 3 | 5.89 [2.20, 15.80] | 3.5 | 0% | 4.00E–04 | 0.03 |
Legge 2016, Yunis 1995, van der Weide 2017, Athanasiou 2011 | HLA-DQB1*05:02 | 33 | 178 | 9 | 521 | 16% | 98% | 99.2% | 7.8% | 2 | 7.12 [1.91, 26.51] | 2.9 | 53% | 3.00E–03 | 0.22 |
Theodoropoulou 1997, Yunis 1995 | HLA-DR2, -DQ1 | 15 | 9 | 18 | 41 | 63% | 69% | 99.5% | 1.8% | 4 | 5.40 [1.58, 18.43] | 2.7 | 0% | 0.01 | 0.511 |
Dettling 2001, Yunis 1995 | HLA-DRB5*02 | 13 | 59 | 2 | 107 | 18% | 98% | 99.2% | 8.3% | 2 | 6.44 [1.57, 26.39] | 2.6 | 0% | 0.01 | 0.73 |
Dettling 2001, Yunis 1995 | HLA-DRB1*16:01 | 13 | 59 | 5 | 104 | 18% | 95% | 99.2% | 3.5% | 3 | 3.62 [1.15, 11.45] | 2.2 | 0% | 0.03 | 1 |
Yunis 1995, Valevski 1998, Dettling 2001 | HLA-B38 | 27 | 29 | 22 | 137 | 48% | 86% | 99.5% | 3.1% | 3 | 10.01 [1.13, 88.55] | 2.1 | 82% | 0.04 | 1 |
Ostrousky 2003, van der Weide 2017 | NQO2 1541 G > A | 40 | 9 | 154 | 167 | 82% | 52% | 99.7% | 1.5% | 7 | 7.16 [0.52, 98.34] | 1.5 | 70% | 0.14 | 1 |
Dettling 2001, Turbay 1997 | HLA-DQB1*03:02 | 16 | 38 | 20 | 111 | 30% | 85% | 99.2% | 1.8% | 6 | 2.31 [0.53, 10.09] | 1.1 | 71% | 0.26 | 1 |
Mosyagin 2004, van der Weide 2017 | CYBA 640 A > G | 78 | 31 | 246 | 70 | 72% | 22% | 98.8% | 0.8% | −16 | 0.70 [0.36, 1.38] | 1.0 | 27% | 0.31 | 1 |
Lahdelma 2001, Yunis 1995 | HLA-B7 | 10 | 32 | 5 | 33 | 24% | 87% | 99.2% | 1.6% | 6 | 2.17 [0.14, 34.50] | 0.6 | 75% | 0.58 | 1 |
Dettling 2001, Yunis 1995 | HLA-DRB4 | 20 | 26 | 53 | 78 | 43% | 60% | 99.1% | 1.0% | 42 | 1.27 [0.35, 4.55] | 0.4 | 69% | 0.72 | 1 |
Dettling 2001, Lahdelma 2001 | HLA-B35 | 10 | 42 | 19 | 87 | 19% | 82% | 99.1% | 1.0% | 52 | 1.08 [0.45, 2.57] | 0.2 | 0% | 0.87 | 1 |
Mosyagin 2004, van der Weide 2017 | MPO −463 G > A | 42 | 70 | 125 | 193 | 38% | 61% | 99.1% | 0.9% | −69 | 1.03 [0.63, 1.68] | 0.1 | 0% | 0.92 | 1 |
