Fig. 4: Protein-drug interactions.
From: Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity
The percent sequence identity distributions of microbial sequences aligned to drug targets with structural information related to drug binding are shown as a combined violin and box plot A. The plots are colored and split into facets by target classification. The difference between protein-drug interactions in drug target (cyan) and microbiome proteins (orange) are depicted B-F. Differences in aligned residues are colored in magenta on the drug target protein structure. The interacting residues between rapamycin and FKBP1A B, tacrine and ACHE C, acetazolamide and CA2 D, fidaxomicin and DNA-directed RNA polymerase subunits rpoB, rpoC, and rpoD E, and trimethoprim and folA F are shown as sticks.
