Fig. 5: Clinical associations with drug target-metaproteome sequency identity.
From: Similarity of drug targets to human microbiome metaproteome promotes pharmacological promiscuity
A bar plot is presented that shows the number of pathogenic, non-pathogenic, and unclassified (“NA”) species that are similar to drug target sequences A. The columns are split to represent the number of species per human and pathogen drug target per metaproteome. A Venn Diagram of the number of shared non-pathogenic species non-selectively targeted by each microbiome is shown B. A Venn Diagram of the shared symptoms related to drugs that were found to be similar (“Yes”) and not similar (“No”) to microbiome metaproteomes C. The percent changes in normalized prevalence of symptoms shared between “Yes” and “No” are plotted and colored by affected high-level organ system or disorder classification D. Only symptoms with more than a 10% change are shown.
