Table 1 The genetic association between major depressive disorder and 12 haplotypes in the generation Scotland: Scottish Family Health Study (GS:SFHS) discovery cohort (where P < 10⁻⁶), the replication cohort (UK Biobank) and a meta-analysis

6^a

108,338,267 − 108,454,437

0.34

1.83 (1.53–2.16)

7.06 × 10 ⁻⁹

1.11 (1.01–1.22)

3.62 × 10 ⁻²

1.26 (1.16–1.37)

3.14 × 10⁻⁷

6

108,407,662–108,454,437

0.25

1.68 (1.42–1.96)

8.17 × 10⁻⁸

1.14 (1.04–1.24)

4.47 × 10 ⁻³

1.25 (1.16–1.35)

4.38 × 10 ⁻⁸

7

139,682,412–139,708,901

0.25

2.17 (1.67–2.73)

4.37 × 10⁻⁷

0.87 (0.68–1.08)

2.20 × 10⁻¹

1.28 (1.08–1.49)

4.67 × 10⁻³

8

79,700,362–80,387,861

0.5

1.98 (1.56–2.46)

9.02 × 10⁻⁷

1.06 (0.86–1.28)

5.93 × 10⁻¹

1.36 (1.18–1.56)

6.29 × 10⁻⁵

8

79,759,499–80,156,474

0.25

1.77 (1.47–2.10)

7.90 × 10⁻⁸

1.05 (0.91–1.21)

5.06 × 10⁻¹

1.28 (1.15–1.42)

1.14 × 10⁻⁵

10

4,588,261–4,822,210

0.5

2.33 (1.83–2.91)

8.50 × 10 ⁻⁹

1.15 (0.80–1.59)

4.39 × 10⁻¹

1.67 (1.40–1.98)

7.92 × 10⁻⁸

11^a

2,260,854–2,437,425

0.41

1.64 (1.38–1.91)

2.86 × 10⁻⁷

1.00 (0.87–1.34)

9.91 × 10⁻¹

1.26 (1.10–1.34)

1.32 × 10⁻⁴

12

48,159,721–48,263,828

0.25

2.00 (1.58–2.47)

4.78 × 10⁻⁷

0.97 (0.79–1.17)

7.36 × 10⁻¹

1.29 (1.12–1.48)

6.51 × 10⁻⁴

12

116,904,503–117,062,860

0.25

2.13 (1.64–2.69)

9.90 × 10⁻⁷

1.04 (0.79–1.34)

7.79 × 10⁻¹

1.45 (1.22–1.71)

5.37 × 10⁻⁵

15

49,206,902–49,260,601

0.25

2.03 (1.62–2.48)

9.21 × 10⁻⁸

1.09 (0.88–1.32)

4.04 × 10⁻¹

1.41 (1.22–1.61)

4.39 × 10⁻⁶

15

93,806,447–93,851,224

0.5

1.58 (1.34–1.83)

4.47 × 10⁻⁷

0.93 (0.81–1.05)

2.38 × 10⁻¹

1.16 (1.05–1.27)

2.50 × 10⁻³

15

93,821,340–93,845,622

0.25

1.52 (1.31–1.75)

8.67 × 10⁻⁷

0.91 (0.81–1.03)

1.37 × 10⁻¹

1.13 (1.03–1.23)

6.97 × 10⁻³