Fig. 3: The presence of Tau-Cy5 alters the morphology of newborn granule neurons
From: Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons
(a) Representative images of RFP-labeled 8-week-old newborn granule neurons in PBS-Cy5- and Tau-Cy5-injected mice. A schematic representation of Sholl's analysis is shown in the image corresponding to a PBS-Cy5-injected mouse. (b–f) Quantification of total dendritic length (b), Sholl's analysis (c), percentage of neurons with several primary apical dendrites (d), length of the apical dendrite (e), and migration into the GL (f) of newborn granule neurons in PBS-Cy5- and Tau-Cy5-injected mice. Tau-Cy5 injection altered the morphology and migration of newborn granule neurons in the DG. ML, molecular; GL, granular layer; H, hilus. In (b, c, e and f) graphs represent mean ± SEM; **0.01 > p ≥ 0.001, ***p < 0.001 (Student´s t-test or Mann–Whitney U test). Graph in (d) represent percentage; ***p < 0.001 (χ 2 test). N = 4 mice per experimental condition. Scale bar: 50 µm
