Fig. 5: Tau-Cy5 selectively alters behavioral pattern separation ability but does not cause alterations in the general behavior of the animals
From: Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons
PBS-Cy5- and Tau-Cy5-injected mice were subjected to pattern separation, motor skills and anxiety-like-related behavioral tests. (a) Memory index (time spent exploring the object placed in the new location/total time of exploration) in the Novel Location Preference test. Tau-Cy5 injection impaired pattern separation skills of the mice. (b) Percentage of time spent in the open arms of the Elevated Plus Maze test. Tau-Cy5 injection did not affect anxiety-like behavior. (c–h) Total distance traveled (c), speed (d), immobility time (e), number of immobile episodes (f), and number of entries (g) and time (h) in the center of the arena in the Open Field test. Tau-Cy5 injection did not alter the anxiety-like and motor behavior of the mice. Graphs represent mean ± SEM; n = 9 mice per experimental condition; **0.01 > p ≥ 0.001 (Student's t-test)
