Fig. 4: Specific bacterial populations are predictive of diffusion tensor measurements in corresponding brain ROIs.

Regression-based ensemble analysis of OTUs and calculated diffusion tensor measurements identified unique populations of gut bacterial genera that are predictive of ROI-specific tensor changes (Table S5). A Circos plot (a) and a hierarchically clustered heatmap (b) illustrate the most robust predictive relationships between OTUs and brain diffusion tensor ROIs identified in our analysis. fa fractional anisotropy, tr trace, rd radial diffusivity, ad axial diffusivity