Fig. 2: Non-linear age-dependent sNSE levels in men and women | Translational Psychiatry

Fig. 2: Non-linear age-dependent sNSE levels in men and women

From: Association between serum neuron-specific enolase, age, overweight, and structural MRI patterns in 901 subjects

Fig. 2

Women show constant low sNSE levels in younger years and increasing levels in higher ages, whereas men show increasing sNSE levels in young adulthood and a decrease in older ages. About an age of 60 years, sNSE values are similar in men and women. Sex-specific differences in the hormonal balance may serve as explanatory approach. After menopause, women have both lower levels of estradiol and testosterone. The missing estradiol-mediated neuroprotective effects may result in increased neural death, showing in increased sNSE levels. sNSE in µg/L

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