Table 1 Neurotransmitter contents

From: Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit

Region

Transmitter

Pheno

Stim

µM/g protein

Two-way ANOVA

DF

F-value

P-value

 

DA

wt

sham

23.185±4.319

Pheno

(1,22)

5.27

0.032a

OFC

  

tDCS

15.630±4.731

Stim

(1,22)

2.82

0.107

  

DAT-tg

sham

13.034±3.740

Interaction

(1,22)

0.0129

0.911

   

tDCS

6.435±3.999

    
 

DOPAC

wt

sham

0.257±0.266

Pheno

(1,21)

37.471

<0.001a

   

tDCS

0.194±0.291

Stim

(1,21)

4.243

0.052

  

DAT-tg

sham

2.353±0.230

Interaction

(1,21)

3.328

0.082

   

tDCS

1.328±0.266

    
 

DA

wt

sham

963.86±52.35

Pheno

(1,23)

247.623

<0.001a

CPu

  

tDCS

1002.0±61.95

Stim

(1,23)

0.146

0.706

  

DAT-tg

sham

129.65±48.97

Interaction

(1,23)

0.105

0.749

   

tDCS

132.78±52.35

    
 

DOPAC

wt

sham

0.052±0.160

Pheno

(1,23)

43.789

<0.001a

   

tDCS

0.052±0.190

Stim

(1,23)

0.497

0.497

  

DAT-tg

sham

1.264±0.150

Interaction

(1,23)

0.495

0.495

   

tDCS

1.035±0.160

    
 

DA

wt

sham

398.19±40.73

Pheno

(1,23)

29.285

<0.001a

Nacc

  

tDCS

390.92±48.19

Stim

(1,23)

0.0359

0.851

  

DAT-tg

sham

171.01±38.11

Interaction

(1,23)

0.00028

0.987

   

tDCS

162.32±40.74

    
 

DOPAC

wt

sham

0.090±0.038

Pheno

(1,22)

45.293

<0.001a

   

tDCS

0.104±0.045

Stim

(1,22)

0.372

0.548

  

DAT-tg

sham

0.354±0.036

Interaction

(1,22)

0.072

0.791

   

tDCS

0.390±0.041

    
  1. OFCorbitofrontal cortex, NAcc nucleus accumbens
  2. Neurochemical content was examined in the DAT-tg and wt rats following sham and tDCS. Dopamine levels and dopamine turnover were measured in the medial OFC, NAcc and CPu. Data are presented as mean ± s.e.m. Asterisks (*) indicate significant differences between phenotype with p < 0.05