Fig. 3: Modafinil effects on control-independent deactivation in schizophrenia group compared to healthy control group are shallower in locus coeruleus and deeper in ventral tegmental area. | Translational Psychiatry

Fig. 3: Modafinil effects on control-independent deactivation in schizophrenia group compared to healthy control group are shallower in locus coeruleus and deeper in ventral tegmental area.

From: Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition

Fig. 3

Contrast maps of SZ group minus HC group, for Control-independent effect of Modafinil Treatment, on activity in locus coeruleus (a) and ventral tegmental area (b). Clusters depicted are small-volume-corrected to p < 0.05. Bar graph depicts mean betas (±s.d.) in statistically significant voxels for SZ (left) and HC (right) groups. Note that the SZ group, compared to the HC group, shows relatively greater activity in LC, i.e., less deactivation, and relatively less activity in VTA, i.e., greater deactivation. See Supplemental Table 5 for characteristics of clusters

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