Fig. 4: Modafinil effects on control-related positive activation in locus coeruleus, ventral tegmental area and neocortical cognitive control network are impaired in schizophrenia group compared to healthy control group. | Translational Psychiatry

Fig. 4: Modafinil effects on control-related positive activation in locus coeruleus, ventral tegmental area and neocortical cognitive control network are impaired in schizophrenia group compared to healthy control group.

From: Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition

Fig. 4

Contrast maps of SZ group minus HC group, for Control-related effect of Modafinil Treatment on activity within locus coeruleus (a), ventral tegmental area (b), and brain as a whole (c). Bar graph depicts mean betas (±s.d.) in statistically significant voxels for SZ (left) and HC (right) groups. Note that the SZ group, compared to the HC group, shows relatively impaired Treatment effects on control-related activity in both subcortical catecholamine brain regions as well as in various regions of the fronto-subcortical cognitive control network. See Supplemental Table 5 for characteristics of clusters meeting corrected threshold

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