Table 2 Association between baseline CRMP1, GSK3β, AKT1, and PKCε mRNA levels and severity of mood symptoms

From: Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder

 

YMRS

MADRS

 

β

95% CI

P

β

95% CI

P

GSK3β (N = 38)

Unadjusteda

2.84

0.36–5.27

<0.02

0.89

−2.35–4.14

<0.60

Adjusteda,b

2.81

0.60–5.51

<0.02

0.76

−2.46–3.99

<0.70

CRMP1 (N = 35)

Unadjusteda

0.45

0.11–0.79

<0.02

0.34

−0.10–0.79

<0.20

Adjusteda,b

0.48

0.13–0.84

<0.009

0.38

−0.05–0.80

<0.09

AKT1 (N = 37)

Unadjusted

1.24

−0.76–3.24

<0.30

1.15

−1.76–4.06

<0.30

Adjustedb

1.39

−0.69–3.47

<0.20

1.35

−1.66–4.35

<0.40

PKCε (N = 36)

Unadjusted

−0.38

−1.93–1.17

<0.70

−1.1

−2.42–0.22

<0.10

Adjustedb

−0.25

−1.72–1.23

<0.80

−0.94

−2.34–0.46

<0.20

  1. CI confidence interval
  2. aSignificant association between the baseline normalized expression levels and severity of mood symptoms
  3. bAdjusted for differences in age and sex, and education for all subjects for the different targeted genes
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