Table 3 Effect of lithium-associated downregulation of CRMP1 and GSK3β and changes in mood severity following 6 weeks of treatment

From: Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder

 

YMRS

MADRS

 

β

95% CI

P

β

95% CI

P

GSK3β (N = 15)

Unadjusted

2.19

−0.09–4.28

<0.05

−0.61

−3.11–1.88

<0.70

Adjusteda

2.43

−0.44–4.41

<0.02

−0.35

−2.92–2.21

<0.80

CRMP1 (N = 13)

Unadjusted

0.37

0.06–0.68

<0.02

0.42

0.03–0.80

<0.04

Adjusteda

0.36

0.06–0.67

<0.02

0.46

0.08–0.84

<0.02

Unadjustedb

0.54

0.15–0.94

<0.007

0.47

−0.06–1.00

<0.08

Adjusteda,b

0.51

0.15–0.88

<0.006

0.52

0.02–1.02

<0.05

  1. aAdjusted for differences in age, sex, and education
  2. bAnalysis excluded data from two BD subjects with undetected CRMP1 mRNA levels
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