Fig. 3: Anatomical location of voxels with significantly different functional connectivity with the posterior cingulate cortex in depression in 125 unmedicated patients vs 254 controls obtained from the voxel-based Association Study (vAS). | Translational Psychiatry

Fig. 3: Anatomical location of voxels with significantly different functional connectivity with the posterior cingulate cortex in depression in 125 unmedicated patients vs 254 controls obtained from the voxel-based Association Study (vAS).

From: Increased functional connectivity of the posterior cingulate cortex with the lateral orbitofrontal cortex in depression

Fig. 3

z values are shown for each voxel, showing the mean difference of functional connectivities for patients with unmedicated depression-controls. Red thus indicates an increase in functional connectivity in depression, and blue a decrease. (The z value shown for each voxel is the sum of the absolute values of the z for each significantly different link to a voxel, with a red color if the sum of the signed values is positive. This enables the effects of different numbers of different links to a voxel to be illustrated. Links are considered only if they are significantly different with p < 0.0001.) The X values are in MNI coordinates. This shows that the main differences are an increase in functional connectivity between the PCC and the lateral orbitofrontal cortex in depression that is unmedicated

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