Fig. 1: Comparative effects of PF-3845, JZL184 and JZL195 on restraint stress-induced anxiety-like behavior in the light–dark box or novelty-induced anxiety-like behavior in the NIH assay. | Translational Psychiatry

Fig. 1: Comparative effects of PF-3845, JZL184 and JZL195 on restraint stress-induced anxiety-like behavior in the light–dark box or novelty-induced anxiety-like behavior in the NIH assay.

From: Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors

Fig. 1

The effects of a-c selective FAAH inhibitor PF-3845 (1 mg kg–1), d-f selective MAGL inhibitor JZL184 (10 mg kg–1) and g-i dual FAAH/MAGL inhibitor JZL195 (10 mg kg–1) systemic administration on the percent light time, percent light distance and total distance traveled in 10 min in the light–dark box assay. The effects of PF-3845 (0.1 and 1 mg kg–1), JZL184 (5, 10 and 15 mg kg–1) and JZL195 (5, 10 and 15 mg kg–1) on the novel cage j latencies and k consumptions in NIH assay. Significant F and P-values from one-way and two-way analysis of variance noted above bar graphs; *P < 0.05, **P < 0.01, ***P < 0.001, vs. respective vehicle-treated group by Holm–Sidak post hoc multiple comparisons test in bar graphs. Data are presented as means ± SEM. NIH novelty-induced hypophagia

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