Fig. 5: Comparative effects of PF-3845, JZL184 and JZL195 on Morris water maze or Barnes-maze performance. | Translational Psychiatry

Fig. 5: Comparative effects of PF-3845, JZL184 and JZL195 on Morris water maze or Barnes-maze performance.

From: Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors

Fig. 5

The effects of a PF-3845 (1 mg kg–1), b JZL184 (8 mg kg–1) and c JZL195 (10 mg kg–1) on escape latency during training days, time spent in target quadrant, mean distance to target and total distance traveled in Morris water maze test. The effects of d PF-3845 (1 mg kg–1), e JZL184 (8 mg kg–1) and f JZL195 (10 mg kg–1) on escape latency during training days, target zone entries, probe trial errors and total distance traveled in the Barnes-maze test. Significant P-values from t-test noted above bar graphs; *P < 0.05, vs vehicle group by unpaired t-test in bar graphs. Data are presented as means ± SEM

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