Fig. 2: Comparison of glutamate, glutamine and GABA concentrations observed by [1H]MRS in the striatum and mPFC of rodent models of ASD and their corresponding controls. | Translational Psychiatry

Fig. 2: Comparison of glutamate, glutamine and GABA concentrations observed by [1H]MRS in the striatum and mPFC of rodent models of ASD and their corresponding controls.

From: Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models

Fig. 2

Left panels: concentrations (in mM) of a glutamate, c glutamine, and e GABA in striatum. Right panels: concentrations (in mM) of b glutamate, d glutamine, and f GABA in mPFC. All the mouse models (colored bars) were on a C57BL/6J background, except for VPA (CD1) and BTBR T+tf/J mice. The rat model (colored bars) was on a Sprague-Dawley background. Wild-type (gray bars) littermates were used as controls, except for VPA and BTBR T+tf/J mice for which age-matched saline-treated CD1 and wild-type C57BL/6J mice served as respective controls. Note the strain-dependent differences in glutamate levels. Data are depicted as mean ± SEM of n = 7–15 per group; *p < 0.05, **p < 0.01, ***p < 0.001; two-tailed t-test. KI knock-in, KO knockout, mPFC medial prefrontal cortex, patDp paternal duplication, VPA valproic acid. For additional data see Supplementary Table 2

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