Table 2 Summary of etiological and behavioral characteristics of rodent models of ASD

From: Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models

Rodent models and their controls

n

Social behavior

Communication

Repetitive behavior

Reference

VPA- vs. saline-treated mice

8 + 7

Impaired

Altered USVs

Increased

27

BTBR T+tf/J vs. C57Bl/6J WT mice

15 + 15

Impaired

Altered USVs

Increased

34

15q11-13 patDp vs. WT mice

10 + 10

Impaired

Altered USVs

No change

28,29,30,– 31

Shank3 KO vs. WT mice

15 + 15

Impaired

Altered USVs

Increased

26, 32

Nlgn3R451C KI vs. WT mice

15 + 14

Impaired

Altered USVs

No change

25

Nlgn3 KO vs. WT rats

12 + 12

Impaired

Altered USVs

Increased

33

  1. All the mouse models were on a C57BL/6J background, except for VPA (CD1) and BTBR T+tf/J mice. The rat model was on a Sprague-Dawley background. Wild-type littermates were used as controls, except for VPA and BTBR T+tf/J mice for which age-matched saline-treated CD1 and wild-type C57BL/6J mice served as respective controls
  2. ASD autism spectrum disorder, KI knock-in, KO knockout, patDp paternal duplication, USVs ultrasonic vocalizations, VPA valproic acid, WT wild type
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